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Literature summary for 5.6.1.6 extracted from
- Intracellular CFTR localization and function (1999), Physiol. Rev., 79, S175-191.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | integral membrane protein | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | Homo sapiens | can function as a chloride-selective anion channel, may also play a role in regulation of the membrane vesicle trafficking and fusion, acidification of organelles and transport of small anions | ADP + phosphate + open Cl- channel | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + closed Cl- channel | chloride channel | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
| ATP + H2O + closed Cl- channel | the chloride channel is regulated by phosphorylation of the R domain and ATP hydrolysis at two nucleotide binding domains | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
| ATP + H2O + closed Cl- channel | can function as a chloride-selective anion channel, may also play a role in regulation of the membrane vesicle trafficking and fusion, acidification of organelles and transport of small anions | Homo sapiens | ADP + phosphate + open Cl- channel | - |
? | |
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