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Literature summary for 5.6.1.5 extracted from

  • Inostroza-Nieves, Y.; Venkatraman, P.; Zavala-Ruiz, Z.
    Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO (2012), Immunol. Lett., 147, 67-74.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte cell line LG-2 EBV B cell Homo sapiens
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Synonyms

Synonyms Comment Organism
19S proteasome
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Homo sapiens
SUG1
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Homo sapiens

General Information

General Information Comment Organism
physiological function Sug1 is necessary for mRNA expression of MHC I and the MHC II-like molecules, HLA-DM and HLA-DOB in B cells. Sug1 is recruited to the proximal promoter of MHC I and II as well as HLA-DM and the beta chain of HLA-DO (HLA-DOB). Sug1 recruitment to MHC promoters is inducible after 2 h of interferon-gamma (IFN-gamma) treatment, followed by CBP and CIITA. Sug1 is required for recruiting CBP and CIITA to MHC I, MHC II and MHC II-like promoters. The expression of Sug1 is also essential for regulating H3 acetylation at the MHC I and II and HLA-DM and HLA-DO promoter Homo sapiens