Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte cell line | LG-2 EBV B cell | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
19S proteasome | - |
Homo sapiens |
SUG1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Sug1 is necessary for mRNA expression of MHC I and the MHC II-like molecules, HLA-DM and HLA-DOB in B cells. Sug1 is recruited to the proximal promoter of MHC I and II as well as HLA-DM and the beta chain of HLA-DO (HLA-DOB). Sug1 recruitment to MHC promoters is inducible after 2 h of interferon-gamma (IFN-gamma) treatment, followed by CBP and CIITA. Sug1 is required for recruiting CBP and CIITA to MHC I, MHC II and MHC II-like promoters. The expression of Sug1 is also essential for regulating H3 acetylation at the MHC I and II and HLA-DM and HLA-DO promoter | Homo sapiens |