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Literature summary for 5.6.1.5 extracted from
- Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7 (2000), J. Biol. Chem., 275, 875-882.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
- |
Thermoplasma sp. |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | Mus musculus | - |
ADP + phosphate + unfolded polypeptide | - |
? |  |
| ATP + H2O + polypeptide | Homo sapiens | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Saccharomyces cerevisiae | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Bos taurus | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Xenopus laevis | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Schizosaccharomyces pombe | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Thermoplasma sp. | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
mouse | - |
| Saccharomyces cerevisiae | - |
- |
- |
| Schizosaccharomyces pombe | - |
- |
- |
| Thermoplasma sp. | - |
acidophilum | - |
| Xenopus laevis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Bos taurus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Mus musculus | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Homo sapiens | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Saccharomyces cerevisiae | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Bos taurus | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Xenopus laevis | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Schizosaccharomyces pombe | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Thermoplasma sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | - |
Xenopus laevis | - |
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | - |
Mus musculus | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Homo sapiens | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Saccharomyces cerevisiae | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Bos taurus | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Xenopus laevis | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Schizosaccharomyces pombe | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Thermoplasma sp. | ADP + phosphate + unfolded polypeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 26S proteasome | - |
Homo sapiens |
| 26S proteasome | - |
Saccharomyces cerevisiae |
| 26S proteasome | - |
Bos taurus |
| 26S proteasome | - |
Xenopus laevis |
| 26S proteasome | - |
Thermoplasma sp. |
| proteasome S4 ATPase | - |
Mus musculus |
| proteasome S4 ATPase | - |
Homo sapiens |
| proteasome S4 ATPase | - |
Saccharomyces cerevisiae |
| proteasome S4 ATPase | - |
Thermoplasma sp. |
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