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Literature summary for 5.6.1.5 extracted from

  • Makino, Y.; Yamano, K.; Kanemaki, M.; Morikawa, K.; Kishimoto, T.; Shimbara, N.; Tanaka, K.; Tamura, T.
    SUG1, a component of the 26 S proteasome, is an ATPase stimulated by specific RNAs (1997), J. Biol. Chem., 272, 23201-23205.
    View publication on PubMed
Search for more literature for 5.6.1.5

Activating Compound

Activating Compound Comment Organism Structure
RNA synthetic and mRNA-type RNAs stimulates activity efficiently Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
gene rSUG1 expressed in Escherichia coli Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
 ATP rSUG1 + 0.001 mg poly(U) Rattus norvegicus
0.03
-
 ATP rSUG1 + 0.0005 mg poly(U) Rattus norvegicus
0.033
-
 ATP rSUG1 + 0.00025 mg poly(U) Rattus norvegicus
0.035
-
 ATP rSUG1 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + polypeptide Homo sapiens
-
 ADP + phosphate + unfolded polypeptide
-
 ?
ATP + H2O + polypeptide Rattus norvegicus
-
 ADP + phosphate + unfolded polypeptide
-
 ?
ATP + H2O + polypeptide Saccharomyces cerevisiae
-
 ADP + phosphate + unfolded polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 rat
-
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Homo sapiens
a
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Rattus norvegicus
a
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Saccharomyces cerevisiae
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + polypeptide
-
 Homo sapiens ADP + phosphate + unfolded polypeptide
-
 ?
ATP + H2O + polypeptide
-
 Rattus norvegicus ADP + phosphate + unfolded polypeptide
-
 ?
ATP + H2O + polypeptide
-
 Saccharomyces cerevisiae ADP + phosphate + unfolded polypeptide
-
 ?
CTP + H2O + polypeptide
-
 Rattus norvegicus CDP + phosphate + unfolded polypeptide
-
 ?
GTP + H2O + polypeptide
-
 Rattus norvegicus GDP + phosphate + unfolded polypeptide
-
 ?
UTP + H2O + polypeptide
-
 Rattus norvegicus UDP + phosphate + unfolded polypeptide
-
 ?

Synonyms

Synonyms Comment Organism
26S proteasome
-
 Homo sapiens
26S proteasome
-
 Rattus norvegicus
26S proteasome
-
 Saccharomyces cerevisiae
p45
-
 Homo sapiens
SUG1
-
 Saccharomyces cerevisiae
SUG1 integral component of 26S proteasome, putative ATPase Rattus norvegicus