Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.1.5 extracted from

  • Rivett, A.J.; Mason, G.G.F.; Murray, R.Z.; Reidlinger, J.
    Regulation of proteasome structure and function (1997), Mol. Biol. Rep., 24, 99-102.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
recombinant subunit, expressed in E. coli, 2D-PAGE Rattus norvegicus
700000
-
-
Rattus norvegicus
700000
-
proteasome, multicatalytic proteinase complex, central catalytic core Saccharomyces cerevisiae
700000
-
proteasome, multicatalytic proteinase complex, central catalytic core Thermoplasma sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + polypeptide Rattus norvegicus
-
ADP + phosphate + unfolded polypeptide
-
?
ATP + H2O + polypeptide Saccharomyces cerevisiae
-
ADP + phosphate + unfolded polypeptide
-
?
ATP + H2O + polypeptide Thermoplasma sp.
-
ADP + phosphate + unfolded polypeptide
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
rat
-
Saccharomyces cerevisiae
-
-
-
Thermoplasma sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
26S proteinase Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Rattus norvegicus
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Saccharomyces cerevisiae
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome Thermoplasma sp.

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + polypeptide
-
Rattus norvegicus ADP + phosphate + unfolded polypeptide
-
?
ATP + H2O + polypeptide
-
Saccharomyces cerevisiae ADP + phosphate + unfolded polypeptide
-
?
ATP + H2O + polypeptide
-
Thermoplasma sp. ADP + phosphate + unfolded polypeptide
-
?