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Literature summary for 5.6.1.4 extracted from

  • Henningsen, U.; Schliwa, M.
    Reversal in the direction of movement of a molecular motor (1997), Nature, 389, 93-96.
    View publication on PubMed
Search for more literature for 5.6.1.4

Cloned(Commentary)

Cloned (Comment) Organism
pt7-7, PCR amplification, chimaera of ncd and Neurospora kinesin, cloned and expressed in Escherichia coli Bl21 Neurospora crassa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
105000
-
 ncd-Nkin chimaera, gel filtration Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Neurospora crassa
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ncd-Nkin chimaera Neurospora crassa

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Neurospora crassa
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Neurospora crassa ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Synonyms

Synonyms Comment Organism
minus end-directed kinesin-like motor protein
-
 Neurospora crassa
ncd
-
 Neurospora crassa