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Literature summary for 5.6.1.4 extracted from

  • Song, H.; Endow, S.A.
    Binding sites on microtubules of kinesin motors of the same or opposite polarity (1996), Biochemistry, 35, 11203-11209.
    View publication on PubMed
Search for more literature for 5.6.1.4

Cloned(Commentary)

Cloned (Comment) Organism
motor domain construct MC6 is expressed in Escherichia coli Drosophila sp. (in: flies)

Inhibitors

Inhibitors Comment Organism Structure
Kar3 Ncd and Kar3, both minus-end motors, severely inhibit the binding of one another to microtubules Drosophila sp. (in: flies)

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule binding-site of Ncd on microtubule Drosophila sp. (in: flies) 5874
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38910
-
 Kar3, molecular mass calculated from the amino acid sequence predicted from the nucleic acid sequence Saccharomyces cerevisiae
41600
-
 ncd, molecular mass calculated from the amino acid sequence predicted from the nucleic acid sequence Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Drosophila melanogaster
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n Drosophila sp. (in: flies)
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n Saccharomyces cerevisiae
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n Xenopus laevis
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Drosophila sp. (in: flies)
-
-
-
Saccharomyces cerevisiae
-
-
-
Xenopus laevis
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Drosophila melanogaster
a
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Saccharomyces cerevisiae
a
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Xenopus laevis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Drosophila melanogaster ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Drosophila sp. (in: flies) ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Saccharomyces cerevisiae ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Xenopus laevis ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Drosophila melanogaster
monomer
-
 Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Kar3
-
 Saccharomyces cerevisiae
minnus-end nonclaret disjunctional kinesin
-
 Drosophila sp. (in: flies)
minus-end nonclaret disjunctional kinesin
-
 Drosophila sp. (in: flies)
ncd
-
 Drosophila melanogaster
ncd
-
 Drosophila sp. (in: flies)