Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BTB-1 | BTB-1 inhibits both of the microtubule-based Kif18A activities. Allosteric BTB-1-binding site near loop5, where it blocks the ATP-dependent conformational changes | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | Homo sapiens | the Kif18A motor domain depolymerizes microtubule plus and minus ends | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NI77 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | the Kif18A motor domain depolymerizes microtubule plus and minus ends | Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KIF18A | - |
Homo sapiens |
kinesin-8 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Kif18A regulates spindle microtubules through its dual functionality (plus-end-directed and minus-end-directed), with microtubule-based stepping and regulation of microtubule dynamics | Homo sapiens |