Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | Mus musculus | the enzyme has a critical role during the metaphase-anaphase transition and cytokinesis. While the MKLP2 neck-linker is directed towards the microtubule plus-end in an ATP-like state, it does not fully dock along the motor domain. The footprint of the MKLP2 motor domain on the microtubule surface is altered compared to motile kinesins, and enhanced by kinesin-6-specific sequences | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | Homo sapiens | the enzyme has a critical role during the metaphase-anaphase transition and cytokinesis. While the MKLP2 neck-linker is directed towards the microtubule plus-end in an ATP-like state, it does not fully dock along the motor domain. The footprint of the MKLP2 motor domain on the microtubule surface is altered compared to motile kinesins, and enhanced by kinesin-6-specific sequences | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95235 | - |
- |
Mus musculus | P97329 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | - |
Mus musculus | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | - |
Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | the enzyme has a critical role during the metaphase-anaphase transition and cytokinesis. While the MKLP2 neck-linker is directed towards the microtubule plus-end in an ATP-like state, it does not fully dock along the motor domain. The footprint of the MKLP2 motor domain on the microtubule surface is altered compared to motile kinesins, and enhanced by kinesin-6-specific sequences | Mus musculus | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | the enzyme has a critical role during the metaphase-anaphase transition and cytokinesis. While the MKLP2 neck-linker is directed towards the microtubule plus-end in an ATP-like state, it does not fully dock along the motor domain. The footprint of the MKLP2 motor domain on the microtubule surface is altered compared to motile kinesins, and enhanced by kinesin-6-specific sequences | Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Synonyms | Comment | Organism |
---|---|---|
kinesin-6 | - |
Mus musculus |
kinesin-6 | - |
Homo sapiens |
MKLP2 | - |
Mus musculus |
MKLP2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme has a critical role during the metaphase-anaphase transition and cytokinesis | Mus musculus |
physiological function | the enzyme has a critical role during the metaphase-anaphase transition and cytokinesis | Homo sapiens |