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Literature summary for 5.6.1.3 extracted from

  • Chakraborty, S.; Zheng, W.
    Decrypting the structural, dynamic, and energetic basis of a monomeric kinesin interacting with a tubulin dimer in three ATPase states by all-atom molecular dynamics simulation (2015), Biochemistry, 54, 859-869.
    View publication on PubMed
Search for more literature for 5.6.1.3

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis, PDB IDs 4HNA, 1BG2, and 1II6, structure modeling Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information modeling reveals allosterically coupled motions driving the APO to ATP transition of ATPase states, binding free energy analysis Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Homo sapiens
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P33176 kinesin-1 heavy chain
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n modeling reveals key nucleotide-dependent changes in the structure and flexibility of the nucleotide-binding pocket and the tubulin-binding site, and allosterically coupled motions driving the APO to ATP transition of ATPase states, extension and shortening of alpha4 helix during the ATPase cycle Homo sapiens ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) structural mechanism of ADP release ?
additional information key residues involved in kinesin-tubulin binding Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer molecular dynamics simulation and atomic details of the structural dynamics and energetics of three major ATPase states (ADP, APO, and ATP state) of a human kinesin-1 monomer in complex with a tubulin dimer Homo sapiens

Synonyms

Synonyms Comment Organism
kinesin-1
-
 Homo sapiens

General Information

General Information Comment Organism
additional information molecular dynamics simulation and atomic details of the structural dynamics and energetics of three major ATPase states (ADP, APO, and ATP state) of a human kinesin-1 monomer in complex with a tubulin dimer Homo sapiens