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Literature summary for 5.6.1.3 extracted from

  • Abualhasan, M.; Good, J.; Wittayanarakul, K.; Anthony, N.; Berretta, G.; Rath, O.; Kozielski, F.; Sutcliffe, O.; MacKay, S.
    Doing the methylene shuffle - Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine (2012), Eur. J. Med. Chem., 54, 483-498.
    View publication on PubMed
Search for more literature for 5.6.1.3

Inhibitors

Inhibitors Comment Organism Structure
(2R)-2-amino-3-((1,1,2-triphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1,1-bis(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(4-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((2-(3,4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((2-(3-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-((2-(4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
-
 Homo sapiens
(2R)-2-amino-3-[(1,1,3-triphenylpropyl)sulfanyl]propanoic acid
-
 Homo sapiens
2-((1,1,2-triphenylethyl)sulfanyl)ethanaminium tetrafluoroborate
-
 Homo sapiens
2-((1,1-bis(4-chlororophenyl)-2-phenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanaminium tetrafluoroborate
-
 Homo sapiens
2-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1-(4-hydroxylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
-
 Homo sapiens
2-((diphenyl(pyridin-4-yl)methyl)sulfanyl)ethanamine
-
 Homo sapiens
2-(tritylthio)ethanamine
-
 Homo sapiens
4-((((2R)-2-ammonio-2-carboxyethyl)sulfanyl)(diphenyl)-methyl)pyridinium tetrafluoroborate
-
 Homo sapiens
S-trityl-L-cysteine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Synonyms

Synonyms Comment Organism
kinesin Eg5
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000586
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
0.0000676
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
0.0001065
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)propanoic acid
0.0001289
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
0.000138
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1,1,2-triphenylethyl)sulfanyl)propanoic acid
0.0001409
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(4-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
0.0001505
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
0.0001594
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(4-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
0.0001676
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
0.0001719
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(4-methylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
0.0001782
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
0.0001859
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens S-trityl-L-cysteine
0.0001912
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
0.0002168
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)propanoic acid
0.0002293
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(3,4-dichlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
0.0002375
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((2-(3-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
0.0002412
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-(tritylthio)ethanamine
0.0002518
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1,1-bis(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
0.0002561
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(3-hydroxyphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
0.000261
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1,1-bis(4-methylphenyl)-2-phenylethyl)sulfanyl)ethanamine
0.0004037
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1,1-bis(4-chlororophenyl)-2-phenylethyl)sulfanyl)ethanamine
0.0004367
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)ethanamine
0.0004558
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((2-(4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
0.0005142
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 4-((((2R)-2-ammonio-2-carboxyethyl)sulfanyl)(diphenyl)-methyl)pyridinium tetrafluoroborate
0.000519
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(3-chlorophenyl)-1,2-diphenylethyl)sulfanyl)ethanaminium tetrafluoroborate
0.0005675
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((1-(3-chlorophenyl)-1-(4-chlorophenyl)-2-phenylethyl)sulfanyl)propanoic acid
0.0005779
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(4-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
0.0005878
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1,1-bis(4-fluorophenyl)-2-phenylethyl)sulfanyl)ethanamine
0.0006656
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(4-hydroxylphenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
0.0006845
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1,1,2-triphenylethyl)sulfanyl)ethanaminium tetrafluoroborate
0.0007895
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((1-(2-fluorophenyl)-1,2-diphenylethyl)sulfanyl)ethanamine
0.0009422
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens 2-((diphenyl(pyridin-4-yl)methyl)sulfanyl)ethanamine
0.005278
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-((2-(3,4-chlorophenyl)-1,1-diphenylethyl)sulfanyl)propanoic acid
0.01584
-
 inhibition of basal ATPase activity, pH not specified in the publication, 25°C Homo sapiens (2R)-2-amino-3-[(1,1,3-triphenylpropyl)sulfanyl]propanoic acid