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Literature summary for 5.6.1.3 extracted from
- A mobile kinesin-head intermediate during the ATP-waiting state (2009), Proc. Natl. Acad. Sci. USA, 106, 5657-5662.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y274A/R278A/K281A | the mutant severely reduces microtubule binding in all nucleotide conditions | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | during the ATP-waiting state, the mobile tethered head of kinesin1 containing ADP can transiently interact with the microtubule | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography and gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + a kinesin associated with a microtubule at position n | - |
Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
| additional information | during the ATP-waiting state, the mobile tethered head of kinesin1 containing ADP can transiently interact with the microtubule | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KIF5B | - |
Homo sapiens |
| kinesin1 | - |
Homo sapiens |
| ubiquitous kinesin1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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