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Literature summary for 5.6.1.3 extracted from
- Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle (2006), Nat. Cell Biol., 8, 913-923.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| microtubuli | ATPase activity of Kip3p is activated by both microtubules and unpolymerized tubulin | Saccharomyces cerevisiae | |
| unpolymerized tubulin | ATPase activity of Kip3p is activated by both microtubules and unpolymerized tubulin | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + a kinesin associated with a microtubule at position n | Saccharomyces cerevisiae | Kip3P is both a plus-end-specific depolymerase and a plus end-directed motor | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + a kinesin associated with a microtubule at position n | Kip3P is both a plus-end-specific depolymerase and a plus end-directed motor | Saccharomyces cerevisiae | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| kinesin-8 | - |
Saccharomyces cerevisiae |
| Kip3p | - |
Saccharomyces cerevisiae |
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