Cloned (Comment) | Organism |
---|---|
subcloning of human kinesin K560 | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00045 | - |
ATP | mutant C330/C4 + NEM | Homo sapiens | |
0.00057 | - |
ATP | mutant C330/C4 | Homo sapiens | |
0.00062 | - |
ATP | mutant C334/C222 | Homo sapiens | |
0.00084 | - |
ATP | mutant C334 | Homo sapiens | |
0.00101 | - |
ATP | wild-type | Homo sapiens | |
0.00119 | - |
ATP | mutant C337/C344 | Homo sapiens | |
0.0012 | - |
ATP | mutant C337 | Homo sapiens | |
0.00124 | - |
ATP | mutant C334 + DTNB | Homo sapiens | |
0.00127 | - |
ATP | wild-type + DTNB | Homo sapiens | |
0.00151 | - |
ATP | mutant C334/C222 + NEM, mutant C337/C344 + DTNB | Homo sapiens | |
0.00159 | - |
ATP | mutant C337 + DTNB | Homo sapiens | |
0.00235 | - |
ATP | mutant C330/C4 + DTNB | Homo sapiens | |
0.00236 | - |
ATP | mutant C334/C222 + DTNB | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | Homo sapiens | - |
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
GTP + H2O + a kinesin associated with a microtubule at position n | Homo sapiens | - |
GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | - |
Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? | |
GTP + H2O + a kinesin associated with a microtubule at position n | - |
Homo sapiens | GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
microtubule-stimulated ATPase | - |
Homo sapiens |