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Literature summary for 5.6.1.3 extracted from

  • Schnapp, B.J.; Crise, B.; Sheetz, M.P.; Reese, T.S.; Khan, S.
    Delayed start-up of kinesin-driven microtubule gliding following inhibition by adenosine 5'-[beta,gamma-imido]triphosphate (1990), Proc. Natl. Acad. Sci. USA, 87, 10053-10057.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.3

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-[beta,gamma-imido]triphosphate nonhydrolyzable analogue of ATP, blocks enzyme by rapid replacement of ATP Doryteuthis pealeii

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Doryteuthis pealeii 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Doryteuthis pealeii
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n Doryteuthis pealeii
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Doryteuthis pealeii
-
 squid
-

Purification (Commentary)

Purification (Comment) Organism
-
 Doryteuthis pealeii

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Doryteuthis pealeii
a

Source Tissue

Source Tissue Comment Organism Textmining
optic lobe
-
 Doryteuthis pealeii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Doryteuthis pealeii ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n
-
 Doryteuthis pealeii GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?