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Literature summary for 5.6.1.2 extracted from

  • DeWitt, M.A.; Cypranowska, C.A.; Cleary, F.B.; Belyy, V.; Yildiz, A.
    The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release (2015), Nat. Struct. Mol. Biol., 22, 73-80 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Saccharomyces cerevisiae 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n Saccharomyces cerevisiae cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a dynein associated with a microtubule at position n Saccharomyces cerevisiae ATCC 204508 cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P36022 dynein heavy chain
-
Saccharomyces cerevisiae ATCC 204508 P36022 dynein heavy chain
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules Saccharomyces cerevisiae ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a dynein associated with a microtubule at position n dynein contains multiple ATPase subunits, with AAA1 serving as the primary catalytic site. ATPase activity at AAA3 is also essential for robust motility. The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release Saccharomyces cerevisiae ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a dynein associated with a microtubule at position n cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules Saccharomyces cerevisiae ATCC 204508 ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a dynein associated with a microtubule at position n dynein contains multiple ATPase subunits, with AAA1 serving as the primary catalytic site. ATPase activity at AAA3 is also essential for robust motility. The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release Saccharomyces cerevisiae ATCC 204508 ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Synonyms

Synonyms Comment Organism
Dyn1
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules Saccharomyces cerevisiae