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Literature summary for 5.6.1.2 extracted from
- Effect of inhibition of axonemal dynein ATPases on the regulation of flagellar and ciliary waveforms in Leishmania parasites (2018), Mol. Biochem. Parasitol., 225, 27-37 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ciliobrevin A | dynein activity of flagellar cells is more strongly inhibited compared to ciliary cells irrespective of the mechanism of inhibition | Leishmania donovani |  |
| erythro-9-(2-hydroxy-3-nonyl)adenine | dynein activity of flagellar cells is more strongly inhibited compared to ciliary cells irrespective of the mechanism of inhibition | Leishmania donovani | |
| vanadate | dynein activity of flagellar cells is more strongly inhibited compared to ciliary cells irrespective of the mechanism of inhibition | Leishmania donovani | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| flagellar axoneme | - |
Leishmania donovani | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| flagellum | the flagellum possesses two waveforms. The flagellar form (tip-to-base) responsible for forward movements and ciliary form (base-to-tip) possibly responsible for reorientation in response to changes in surroundings. Dyneins responsible for the two waveforms in Leishmania bear different structural and functional conformations. During ciliary beating, there is heterogeneity along the flagellum | Leishmania donovani | - |
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