Cloned (Comment) | Organism |
---|---|
- |
Dictyostelium discoideum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Dictyostelium discoideum | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a dynein associated with a microtubule at position n | Dictyostelium discoideum | dynein is a motor protein that moves on microtubules using the energy of adenosine triphosphate hydrolysis | ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | P34036 | dynein heavy chain | - |
Purification (Comment) | Organism |
---|---|
- |
Dictyostelium discoideum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a dynein associated with a microtubule at position n | dynein is a motor protein that moves on microtubules using the energy of adenosine triphosphate hydrolysis | Dictyostelium discoideum | ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end) | - |
? | |
ATP + H2O + a dynein associated with a microtubule at position n | dynein is a motor protein that moves on microtubules using the energy of adenosine triphosphate hydrolysis. The alpha-tubulin residues R403 and E416 are critical for ATPase activation and directional movement of dynein. These residues form salt bridges with the residues in the dynein microtubule-binding domain that work in concert to induce registry change in the stalk coiled coil and activate the ATPase. The R403-E3390 salt bridge functions as a switch for this mechanism because of its reversed charge relative to other residues at the interface | Dictyostelium discoideum | ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end) | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | dynein is a motor protein that moves on microtubules using the energy of adenosine triphosphate hydrolysis | Dictyostelium discoideum |