Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.1.2 extracted from

  • Firestone, A.J.; Weinger, J.S.; Maldonado, M.; Barlan, K.; Langston, L.D.; ODonnell, M.; Gelfand, V.I.; Kapoor, T.M.; Chen, J.K.
    Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein (2012), Nature, 484, 125-129.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.2

Cloned(Commentary)

Cloned (Comment) Organism
dynein motor domain Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile ciliobrevin D, at 0.025 mM about 50% inhibition Bos taurus
2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile ciliobrevin D Rattus norvegicus
3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile ciliobrevin A, at 0.1 mM more than 50% inhibition Bos taurus
3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile ciliobrevin A Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
cytoplasm
-
 Bos taurus 5737
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n
-
 Rattus norvegicus ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a dynein associated with a microtubule at position n
-
 Bos taurus ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Synonyms

Synonyms Comment Organism
AAA+ ATPase motor cytoplasmic dynein
-
 Rattus norvegicus
AAA+ ATPase motor cytoplasmic dynein
-
 Bos taurus