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Literature summary for 5.6.1.2 extracted from

  • Walter, W.J.; Brenner, B.; Steffen, W.
    Cytoplasmic dynein is not a conventional processive motor (2010), J. Struct. Biol., 170, 266-269.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Sus scrofa 5737
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
at 0.001 mM ATP cytoplasm dynein only performed discrete single binding events. At this low ATP concentration dynein behaves as a non-processive motor. At low ATP dynein undergoes a -8 nm apparent working stroke and the lifetime of these binding events depends on ATP concentration Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n the cytoplasmic dynein is a non-processive motor at low ATP concentrations. Processivity can be restored even in the absence of dynactin by increasing the ATP concentration to 0.1 mM Sus scrofa ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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Synonyms

Synonyms Comment Organism
dynein
-
Sus scrofa