Literature summary for 5.6.1.2 extracted from

McNaughton, L.; Tikhonenko, I.; Banavali, N.K.; LeMaster, D.M.; Koonce, M.P.
A low affinity ground state conformation for the dynein microtubule binding domain (2010), J. Biol. Chem., 285, 15994-16002.

Crystallization (Commentary)

Crystallization (Comment)	Organism
the active sites for microtubule binding and ATP hydrolysis communicate via conformational changes transduced through a ca. 10 nm length antiparallel coilded-coil stalk, which connects the binding domain to the roughly 300 kDa motor core. A balancing of opposing conformations in the stalk and microtubule binding domain (MTBD) enables modest ling-range interactions arising from ATP-binding in the motor core to induce a relaxation of the MTBD into the stable low affinity state	Dictyostelium discoideum

Crystallization (Comment)

Organism

the active sites for microtubule binding and ATP hydrolysis communicate via conformational changes transduced through a ca. 10 nm length antiparallel coilded-coil stalk, which connects the binding domain to the roughly 300 kDa motor core. A balancing of opposing conformations in the stalk and microtubule binding domain (MTBD) enables modest ling-range interactions arising from ATP-binding in the motor core to induce a relaxation of the MTBD into the stable low affinity state

Dictyostelium discoideum

Organism

Organism	UniProt	Comment	Textmining
Dictyostelium discoideum	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + H2O + a dynein associated with a microtubule at position n = ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)	the active sites for microtubule binding and ATP hydrolysis communicate via conformational changes transduced through a ca. 10 nm length antiparallel coilded-coil stalk, which connects the binding domain to the roughly 300 kDa motor core. A balancing of opposing conformations in the stalk and microtubule binding domain (MTBD) enables modest ling-range interactions arising from ATP-binding in the motor core to induce a reaxation of the MTBD into the stable low affinity state	Dictyostelium discoideum	a

Synonyms

Synonyms	Comment	Organism
dynein	-	Dictyostelium discoideum

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Release 2023.1 (January 2023)