Literature summary for 5.6.1.2 extracted from

Mesngon, M.T.; Tarricone, C.; Hebbar, S.; Guillotte, A.M.; Schmitt, E.W.; Lanier, L.; Musacchio, A.; King, S.J.; Smith, D.S.
Regulation of cytoplasmic dynein ATPase by Lis1 (2006), J. Neurosci., 26, 2132-2139.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Lis1	stimulates the average in vitro enzymatic activity of dynein by 40%. A subpopulation of brain dynein binds Lis1. ATPase activity is substantially higher for dynein motors that interact with Lis1. It is proposed that modulation of the Lis1-dynein-interaction serves as a control point in motor regulation	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Bos taurus	5737	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + a dynein associated with a microtubule at position n	-	Bos taurus	ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)	-	?

Synonyms

Synonyms	Comment	Organism
dynein ATPase	-	Bos taurus

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Release 2023.1 (January 2023)