Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
axon | Tctex-1 is enriched in growing axons of cultured hippocampal neurons. The cytoplasmic dynein light chain Tctex-1 plays a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration. The neuritogenic effects elicited by Tctex-1 are independent from its cargo adaptor role for dynein motor transport. The selective high level of Tctex-1 at the growth cone of growing axons drives fast neurite extension by modulating actin dynamics and also Rac1 activity | Rattus norvegicus | 30424 | - |
cytoplasm | - |
Rattus norvegicus | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | hippocampal neuron. Tctex-1 is enriched in growing axons of cultured hippocampal neurons. The cytoplasmic dynein light chain Tctex-1 plays a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration. The neuritogenic effects elicited by Tctex-1 are independent from its cargo adaptor role for dynein motor transport. The selective high level of Tctex-1 at the growth cone of growing axons drives fast neurite extension by modulating actin dynamics and also Rac1 activity | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a dynein associated with a microtubule at position n | - |
Rattus norvegicus | ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end) | - |
? | |
additional information | the cytoplasmic dynein light chain Tctex-1 plays a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration. The neuritogenic effects elicited by Tctex-1 are independent from its cargo adaptor role for dynein motor transport. the selective high level of Tctex-1 at the growth cone of growing axons drives fast neurite extension by modulating actin dynamics and also Rac1 activity: Tctex-1 may act as a regulatory link between the microtubule and microfilament cytoskeleton | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dynein light chain Tctex-1 | - |
Rattus norvegicus |
Tctex-1 | dynein light chain | Rattus norvegicus |