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Literature summary for 5.6.1.2 extracted from

  • Kumar, S.; Lee, I.H.; Plamann, M.
    Cytoplasmic dynein ATPase activity is regulated by dynactin-dependent phosphorylation (2000), J. Biol. Chem., 275, 31798-31804.
    View publication on PubMed
Search for more literature for 5.6.1.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
200
-
 ATP in the presence of microtubules Neurospora crassa
400
-
 ATP in the absence of microtubules Neurospora crassa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm microtubule-associated enzyme Neurospora crassa 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n Neurospora crassa
-
 ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 240.00 pmol/min/ml, in the absence of microtubules, activity is regulated by dynactin-dependent phosphorylation of dynein light chains, enzyme is activated by dephosphorylation Neurospora crassa
additional information
-
 400.00 pmol/min/ml, in the presence of microtubules, activity is regulated by dynactin-dependent phosphorylation of dynein light chains, enzyme is activated by dephosphorylation Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a dynein associated with a microtubule at position n
-
 Neurospora crassa ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a dynein associated with a microtubule at position n hydrolysis stimulated 2fold by microtubules at an ATP concentration of 4 mM Neurospora crassa ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
-
 ?