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Literature summary for 5.6.1.1 extracted from

  • Waclawek, E.; Joachimiak, E.; Hall, M.H.; Fabczak, H.; Wloga, D.
    Regulation of katanin activity in the ciliate Tetrahymena thermophila (2017), Mol. Microbiol., 103, 134-150 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
p80 KAT3p dual character of p80 KAT3p as both an activator and a repressor of p60 KAT1p Tetrahymena thermophila

Inhibitors

Inhibitors Comment Organism Structure
p80 KAT3p dual character of p80 KAT3p as both an activator and a repressor of p60 KAT1p Tetrahymena thermophila

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule p60 KAT1p localizes near the basal bodies and in cilia, but also co-localizes with the microtubules of the contractile vacuole. Increased levels of tubulin polyglutamylation correlates with a relocalization of p60 KAT1p to glutamylated microtubules Tetrahymena thermophila 5874
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + microtubule Tetrahymena thermophila katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation ADP + phosphate + alpha/beta tubulin heterodimers
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?
ATP + H2O + microtubule Tetrahymena thermophila CU428.2 katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation ADP + phosphate + alpha/beta tubulin heterodimers
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?

Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila
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-
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Tetrahymena thermophila CU428.2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + microtubule katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation Tetrahymena thermophila ADP + phosphate + alpha/beta tubulin heterodimers
-
?
ATP + H2O + microtubule activity of katanin requires specific domains of both p60 KAT1p catalytic subunit and p80 KAT3p regulatory subunit. In addition to its activating role, p80 can also contribute to the inhibition of p60 KAT1p. Increased levels of tubulin polyglutamylation correlates with a relocalization of p60 KAT1p to glutamylated microtubules, suggesting that binding of katanin subunits to microtubules is regulated differently and that initial binding of katanin p60 KAT1p but not p80 KAT3p is stimulated by glutamylation Tetrahymena thermophila ADP + phosphate + alpha/beta tubulin heterodimers
-
?
ATP + H2O + microtubule katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation Tetrahymena thermophila CU428.2 ADP + phosphate + alpha/beta tubulin heterodimers
-
?
ATP + H2O + microtubule activity of katanin requires specific domains of both p60 KAT1p catalytic subunit and p80 KAT3p regulatory subunit. In addition to its activating role, p80 can also contribute to the inhibition of p60 KAT1p. Increased levels of tubulin polyglutamylation correlates with a relocalization of p60 KAT1p to glutamylated microtubules, suggesting that binding of katanin subunits to microtubules is regulated differently and that initial binding of katanin p60 KAT1p but not p80 KAT3p is stimulated by glutamylation Tetrahymena thermophila CU428.2 ADP + phosphate + alpha/beta tubulin heterodimers
-
?

Subunits

Subunits Comment Organism
heterodimer composed of an AAA domain catalytic subunit, p60, and a regulatory subunit, a WD40 repeat protein, p80 Tetrahymena thermophila

Synonyms

Synonyms Comment Organism
p60 KAT1p
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Tetrahymena thermophila

Expression

Organism Comment Expression
Tetrahymena thermophila overexpression of both, p80 KAT3p and p60 KAT1p enhances the rate of disassembly of microtubular structures as compared with overexpression of p60 KAT1p alone up

General Information

General Information Comment Organism
physiological function katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation Tetrahymena thermophila