Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p80 KAT3p | dual character of p80 KAT3p as both an activator and a repressor of p60 KAT1p | Tetrahymena thermophila |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p80 KAT3p | dual character of p80 KAT3p as both an activator and a repressor of p60 KAT1p | Tetrahymena thermophila |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | p60 KAT1p localizes near the basal bodies and in cilia, but also co-localizes with the microtubules of the contractile vacuole. Increased levels of tubulin polyglutamylation correlates with a relocalization of p60 KAT1p to glutamylated microtubules | Tetrahymena thermophila | 5874 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + microtubule | Tetrahymena thermophila | katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation | ADP + phosphate + alpha/beta tubulin heterodimers | - |
? | |
ATP + H2O + microtubule | Tetrahymena thermophila CU428.2 | katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation | ADP + phosphate + alpha/beta tubulin heterodimers | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tetrahymena thermophila | - |
- |
- |
Tetrahymena thermophila CU428.2 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + microtubule | katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation | Tetrahymena thermophila | ADP + phosphate + alpha/beta tubulin heterodimers | - |
? | |
ATP + H2O + microtubule | activity of katanin requires specific domains of both p60 KAT1p catalytic subunit and p80 KAT3p regulatory subunit. In addition to its activating role, p80 can also contribute to the inhibition of p60 KAT1p. Increased levels of tubulin polyglutamylation correlates with a relocalization of p60 KAT1p to glutamylated microtubules, suggesting that binding of katanin subunits to microtubules is regulated differently and that initial binding of katanin p60 KAT1p but not p80 KAT3p is stimulated by glutamylation | Tetrahymena thermophila | ADP + phosphate + alpha/beta tubulin heterodimers | - |
? | |
ATP + H2O + microtubule | katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation | Tetrahymena thermophila CU428.2 | ADP + phosphate + alpha/beta tubulin heterodimers | - |
? | |
ATP + H2O + microtubule | activity of katanin requires specific domains of both p60 KAT1p catalytic subunit and p80 KAT3p regulatory subunit. In addition to its activating role, p80 can also contribute to the inhibition of p60 KAT1p. Increased levels of tubulin polyglutamylation correlates with a relocalization of p60 KAT1p to glutamylated microtubules, suggesting that binding of katanin subunits to microtubules is regulated differently and that initial binding of katanin p60 KAT1p but not p80 KAT3p is stimulated by glutamylation | Tetrahymena thermophila CU428.2 | ADP + phosphate + alpha/beta tubulin heterodimers | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | composed of an AAA domain catalytic subunit, p60, and a regulatory subunit, a WD40 repeat protein, p80 | Tetrahymena thermophila |
Synonyms | Comment | Organism |
---|---|---|
p60 KAT1p | - |
Tetrahymena thermophila |
Organism | Comment | Expression |
---|---|---|
Tetrahymena thermophila | overexpression of both, p80 KAT3p and p60 KAT1p enhances the rate of disassembly of microtubular structures as compared with overexpression of p60 KAT1p alone | up |
General Information | Comment | Organism |
---|---|---|
physiological function | katanin-dependent severing of microtubules is important for proper execution of key cellular activities including cell division, migration, and differentiation | Tetrahymena thermophila |