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Literature summary for 5.6.1.1 extracted from

  • Onitake, A.; Matsushita-Ishiodori, Y.; Johjima, A.; Esaki, M.; Ogura, T.; Yamanaka, K.
    The C-terminal alpha-helix of SPAS-1, a Caenorhabditis elegans spastin homologue, is crucial for microtubule severing (2012), J. Struct. Biol., 179, 138-142.
    View publication on PubMed
Search for more literature for 5.6.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3), FLAG tagged versions expressed in HEK293 cells Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
K437P/K441P predicted not to form the C-terminal alpha-helix, microtuble network remains in mutant protein expressing HEK293 cells Caenorhabditis elegans
additional information C-terminal deletion mutants: 1-432, 1-435, 1-447, C-terminal alpha-helix is essential for microtuble severing Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q8MNV0
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Caenorhabditis elegans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O microtuble-stimulated Caenorhabditis elegans ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
homohexamer SDS-PAGE, gel filtration Caenorhabditis elegans

Synonyms

Synonyms Comment Organism
SPAS-1 spastin homologue Caenorhabditis elegans
spastin
-
 Caenorhabditis elegans