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Literature summary for 5.6.1.1 extracted from

  • Yu, W.; Qiang, L.; Solowska, J.M.; Karabay, A.; Korulu, S.; Baas, P.W.
    The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches (2008), Mol. Biol. Cell, 19, 1485-1498.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
additional information overexpression of katanin results in 12% loss of microtubule mass, low degradation of microtubule array in katanin-overexpressing neurons Rattus norvegicus
additional information overexpression of spastin result in 30% loss of microtubule mass, increase in axonal branching in spastin-overexpressing neurons, degrade of microtubule array in spastin-overexpressing neurons Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information slowed development, shorter axons and fewer axonal branches in spastin-depleted neurons Rattus norvegicus
protein tau affords protection of microtubules in katanin-overexpressing neurons Rattus norvegicus
Tau affords some protection of microtubules in spastin-overexpressing neurons Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Rattus norvegicus
-
hippocampal cell line
-
 Rattus norvegicus
-
RFL-6 cell
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
kananin
-
 Rattus norvegicus
P60-kananin
-
 Rattus norvegicus
spastin isoform M85 Rattus norvegicus