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Literature summary for 5.6.1.1 extracted from

  • Davis, L.J.; Odde, D.J.; Block, S.M.; Gross, S.P.
    The importance of lattice defects in katanin-mediated microtubule severing in vitro (2002), Biophys. J., 82, 2916-2927.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Echinoidea enzyme acts on defects in microtubule lattice, promotes loss of tubulin at the defect site until the two microtubule segments are held together so weakly that mechanically unconstrained microtubules kink at the defect site ?
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 ?

Organism

Organism UniProt Comment Textmining
Echinoidea
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 recombinant enzyme expressed in Baculovirus/Sf9 system
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Reaction

Reaction Comment Organism Reaction ID
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers model of enzyme activity based on defect-containing microtubules Echinoidea
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme acts on defects in microtubule lattice, promotes loss of tubulin at the defect site until the two microtubule segments are held together so weakly that mechanically unconstrained microtubules kink at the defect site Echinoidea ?
-
 ?