Literature summary for 5.5.1.6 extracted from

Ruiz-Pernia, J.J.; Silla, E.; Tunon, I.
Comparative computational analysis of different active site conformations and substrates in a chalcone isomerase catalyzed reaction (2006), J. Phys. Chem. B, 110, 20686-20692.

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Organism

Organism	UniProt	Comment	Textmining
Medicago sativa	P28012	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
A chalcone = a flavanone	rate limiting step is an intramolecular Michael addition of a 2-oxyanion to the alpha,beta-double bond. Computational study shows that the active site conformation with larger catalytic power presents a positively charged lysine resiude much closer to the substrate than the second active site. Charge is transferred from the 2-oxyanion to the beta-carbon atom	Medicago sativa	a

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Release 2023.1 (January 2023)