Literature summary for 5.5.1.4 extracted from

Frej, A.D.; Clark, J.; Le Roy, C.I.; Lilla, S.; Thomason, P.A.; Otto, G.P.; Churchill, G.; Insall, R.H.; Claus, S.P.; Hawkins, P.; Stephens, L.; Williams, R.S.
The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles (2016), Mol. Cell. Biol., 36, 1464-1479 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-glucose 6-phosphate	Dictyostelium discoideum	-	1D-myo-inositol 3-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Dictyostelium discoideum	Q54N49	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose 6-phosphate	-	Dictyostelium discoideum	1D-myo-inositol 3-phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 80000, red fluorescent protein-tagged enzyme, SDS-PAGE	Dictyostelium discoideum

Synonyms

Synonyms	Comment	Organism
INO1	-	Dictyostelium discoideum
inositol-3-phosphate synthase	-	Dictyostelium discoideum

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	required	Dictyostelium discoideum

General Information

General Information	Comment	Organism
malfunction	enzyme loss causes a pleiotropic phenotype, triggers inositol depletion and results in an inositol auxotrophy	Dictyostelium discoideum

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Release 2023.1 (January 2023)