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Literature summary for 5.5.1.4 extracted from
- Human 1D-myo-inositol 3-phosphate synthase is functional in yeast (2004), J. Biol. Chem., 279, 21759-21765.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NH4+ | 5 mM, 5fold increase in activity | Homo sapiens |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Valproate | slight inhibition | Homo sapiens | |
| Zn2+ | 1 mM, 5fold decrease in activity | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
NAD+ | - |
Homo sapiens | |
| 0.57 | - |
glucose 6-phosphate | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 10 mM, 2fold stimulation | Homo sapiens | |
| K+ | 10 mM, 5fold stimulation | Homo sapiens | |
| Mg2+ | 1-10 mM, 2-3fold stimulation | Homo sapiens | |
| Mn2+ | 1-10 mM, 2-3fold stimulation | Homo sapiens | |
| Na+ | 10 mM, 2fold stimulation | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose 6-phosphate | Homo sapiens | rate-limiting step for de novo inositol biosynthesis | 1D-myo-inositol 3-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose 6-phosphate | - |
Homo sapiens | 1D-myo-inositol 3-phosphate | - |
? | |
| D-glucose 6-phosphate | rate-limiting step for de novo inositol biosynthesis | Homo sapiens | 1D-myo-inositol 3-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MIP synthase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
20 min, stable up to | Homo sapiens |
| 60 | - |
20 min, approximately 60% loss of activity | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
at 37°C | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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