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Literature summary for 5.5.1.33 extracted from

  • Li, S.; Lowell, A.; Newmister, S.; Yu, F.; Williams, R.; Sherman, D.
    Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids (2017), Nat. Chem. Biol., 13, 467-469 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.5.1.33

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Fischerella sp. SAG 46.79
expression in Escherichia coli Fischerella muscicola

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole Fischerella sp. SAG 46.79
-
 12-epi-fischerindole U
-
 ?

Organism

Organism UniProt Comment Textmining
Fischerella muscicola A0A1L1VVY8
-
-
Fischerella muscicola UTEX 1829 A0A1L1VVY8
-
-
Fischerella sp. SAG 46.79 A0A1P8VSL7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole
-
 Fischerella sp. SAG 46.79 12-epi-fischerindole U
-
 ?
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole
-
 Fischerella muscicola 12-epi-fischerindole U
-
 ?
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole
-
 Fischerella muscicola UTEX 1829 12-epi-fischerindole U
-
 ?

Synonyms

Synonyms Comment Organism
fimC5
-
 Fischerella muscicola
fisC
-
 Fischerella sp. SAG 46.79

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Fischerella sp. SAG 46.79
37
-
 assay at Fischerella muscicola

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Fischerella sp. SAG 46.79
7.8
-
 assay at Fischerella muscicola

General Information

General Information Comment Organism
physiological function enzyme is involved in ring formation and stereochemical control in the biosynthesis of fischerindoles. FisC directly produces 12-epi-fischerindole U Fischerella sp. SAG 46.79
physiological function enzyme is involved in ring formation and stereochemical control in the biosynthesis of fischerindoles. FisC directly produces 12-epi-fischerindole U Fischerella muscicola