Literature summary for 5.5.1.32 extracted from

Li, S.; Lowell, A.N.; Yu, F.; Raveh, A.; Newmister, S.A.; Bair, N.; Schaub, J.M.; Williams, R.M.; Sherman, D.H.
Hapalindole/ambiguine biogenesis is mediated by a cope rearrangement, C-C bond-forming cascade (2015), J. Am. Chem. Soc., 137, 15366-15369 .

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Organism

Organism	UniProt	Comment	Textmining
Fischerella ambigua	A0A076N4W8	-	-
Fischerella ambigua UTEX 19030	A0A076N4W8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole	-	Fischerella ambigua	12-epi-hapalindole U	-	?
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole	-	Fischerella ambigua UTEX 19030	12-epi-hapalindole U	-	?

Synonyms

Synonyms	Comment	Organism
famC1	-	Fischerella ambigua

General Information

General Information	Comment	Organism
physiological function	aromatic prenyltransferase FamD2 and FamC1 act in concert to form the tetracyclic core ring system of the hapalindoles from cis-indole isonitrile and geranyl diphosphate through a presumed biosynthetic Cope rearrangement and subsequent 6-exo-trig cyclization/electrophilic aromatic substitution reaction	Fischerella ambigua

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Release 2023.1 (January 2023)