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Literature summary for 5.5.1.31 extracted from

  • Li, S.; Lowell, A.; Newmister, S.; Yu, F.; Williams, R.; Sherman, D.
    Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids (2017), Nat. Chem. Biol., 13, 467-469 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.5.1.31

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Fischerella ambigua

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole Fischerella ambigua
-
 hapalindole H
-
 ?
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole Fischerella ambigua UTEX 1903
-
 hapalindole H
-
 ?

Organism

Organism UniProt Comment Textmining
Fischerella ambigua V5TD11 and A0A076N8Z0 V5TD11 i.e. subunit FamC2, A0A076N8Z0 i.e. subunit FamC3
-
Fischerella ambigua UTEX 1903 V5TD11 and A0A076N8Z0 V5TD11 i.e. subunit FamC2, A0A076N8Z0 i.e. subunit FamC3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole
-
 Fischerella ambigua hapalindole H
-
 ?
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole
-
 Fischerella ambigua UTEX 1903 hapalindole H
-
 ?

Synonyms

Synonyms Comment Organism
ambU2
-
 Fischerella ambigua
famC3
-
 Fischerella ambigua

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Fischerella ambigua

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Fischerella ambigua

General Information

General Information Comment Organism
physiological function enzyme is involved in ring formation and stereochemical control in the biosynthesis of hapalindoles. Hapalindole H is assembled by a heterodimeric combination of FamC2 and FamC3 Fischerella ambigua