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Literature summary for 5.5.1.30 extracted from

  • Lemke, C.; Roach, K.; Ortega, T.; Tantillo, D.J.; Siegel, J.B.; Peters, R.J.
    Investigation of acid-base catalysis in halimadienyl diphosphate synthase involved in Mycobacterium tuberculosis virulence (2022), ACS Bio Med Chem Au, 2, 490-498.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate Mycobacterium tuberculosis the enzyme produces small amounts of halima-5,13-dienyl diphosphate and labda-8,13-dienyl diphosphate, along with trace amounts of labda-7,13-dienyl diphosphate, as well as an unknown product halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
-
 ?
geranylgeranyl diphosphate Mycobacterium tuberculosis H37Rv the enzyme produces small amounts of halima-5,13-dienyl diphosphate and labda-8,13-dienyl diphosphate, along with trace amounts of labda-7,13-dienyl diphosphate, as well as an unknown product halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
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Mycobacterium tuberculosis H37Rv
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate the enzyme produces small amounts of halima-5,13-dienyl diphosphate and labda-8,13-dienyl diphosphate, along with trace amounts of labda-7,13-dienyl diphosphate, as well as an unknown product Mycobacterium tuberculosis halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
-
 ?
geranylgeranyl diphosphate the enzyme produces small amounts of halima-5,13-dienyl diphosphate and labda-8,13-dienyl diphosphate, along with trace amounts of labda-7,13-dienyl diphosphate, as well as an unknown product Mycobacterium tuberculosis H37Rv halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
-
 ?

Synonyms

Synonyms Comment Organism
HPS:F171A mutant F171A of class II diterpene cyclase Rv3377c Mycobacterium tuberculosis