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Literature summary for 5.5.1.23 extracted from

  • Dickens, M.L.; Ye, J.; Strohl, W.R.
    Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5 (1995), J. Bacteriol., 177, 536-543.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Streptomyces sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18495
-
x * 18495, calculated from sequence Streptomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methyl aklanonate Streptomyces sp. the enzyme is involved in the biosynthesis of the anthracycline daunorubicin aklaviketone
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces sp. Q55215
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Streptomyces sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methyl aklanonate
-
Streptomyces sp. aklaviketone
-
?
methyl aklanonate the enzyme is involved in the biosynthesis of the anthracycline daunorubicin Streptomyces sp. aklaviketone
-
?

Subunits

Subunits Comment Organism
? x * 18495, calculated from sequence Streptomyces sp.

Synonyms

Synonyms Comment Organism
AAME cyclase
-
Streptomyces sp.
DauD
-
Streptomyces sp.
methyl aklanonate cyclase
-
Streptomyces sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7.5 AAME cyclase activity is observed at both pH 7.5 and pH 6.0, suggesting that it has a broad optimal pH range for activity Streptomyces sp.

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of the anthracycline daunorubicin Streptomyces sp.