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Literature summary for 5.4.99.B40 extracted from

  • Jin, J.; Moore, M.K.; Wilson, W.K.; Matsuda, S.P.T.
    Astertarone A synthase from chinese cabbage does not produce the C4-epimer mechanistic insights (2018), Org. Lett., 20, 1802-1805 .
    View publication on PubMed
Search for more literature for 5.4.99.B40

Cloned(Commentary)

Cloned (Comment) Organism
gene bra032185, DNA and amino acid sequence analysis, sequence comparisons, and phylogenetic analysis Brassica rapa subsp. pekinensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(3S)-2,3-epoxy-2,3-dihydrosqualene Brassica rapa subsp. pekinensis
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 astertarone A
-
 ?
additional information Brassica rapa subsp. pekinensis the Brassica rapa oxidosqualene cyclase Bra032185 produces 60% astertarone A and 20 minor triterpenes (0.1-11%), i.e. butyrospermol (11.4%), euphol (8.6%), dammar-21-ene-3beta,18(S)-diol (6.7%), boeticol (4.2%), dammar-21-ene-3beta,18(R)-diol (1.8%), isoeuphol (1.4%), dammar-18(28)-21-dien-3-beta-ol (1.2%), camelliol C (1.0%), and below 1% of isohelianol, 9alphaH-polypoda-7,13E,17E,21-tetraenol, isotirucallol, (20R)--dammara-12,21-dien-3beta-ol, 9alphaH-polypoda-8(26),13E,17E,21-tetraenol, 14-epiarabindiol, (18S)-dammara-12,21-dien-3beta-ol, dammara-18(19)Z-21-dien-3beta-ol, and dammara-18(19)E,21-dien-3-beta-ol ?
-
 ?

Organism

Organism UniProt Comment Textmining
Brassica rapa subsp. pekinensis M4ETQ3
-
-

Reaction

Reaction Comment Organism Reaction ID
(3S)-2,3-epoxy-2,3-dihydrosqualene = astertarone A reaction mechanism via intermediate forms dammarenyl cation, C-4 cation, and enol form, overview Brassica rapa subsp. pekinensis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-2,3-epoxy-2,3-dihydrosqualene
-
 Brassica rapa subsp. pekinensis astertarone A
-
 ?
additional information the Brassica rapa oxidosqualene cyclase Bra032185 produces 60% astertarone A and 20 minor triterpenes (0.1-11%), i.e. butyrospermol (11.4%), euphol (8.6%), dammar-21-ene-3beta,18(S)-diol (6.7%), boeticol (4.2%), dammar-21-ene-3beta,18(R)-diol (1.8%), isoeuphol (1.4%), dammar-18(28)-21-dien-3-beta-ol (1.2%), camelliol C (1.0%), and below 1% of isohelianol, 9alphaH-polypoda-7,13E,17E,21-tetraenol, isotirucallol, (20R)--dammara-12,21-dien-3beta-ol, 9alphaH-polypoda-8(26),13E,17E,21-tetraenol, 14-epiarabindiol, (18S)-dammara-12,21-dien-3beta-ol, dammara-18(19)Z-21-dien-3beta-ol, and dammara-18(19)E,21-dien-3-beta-ol Brassica rapa subsp. pekinensis ?
-
 ?

Synonyms

Synonyms Comment Organism
Bra032185
-
 Brassica rapa subsp. pekinensis

General Information

General Information Comment Organism
evolution the enzyme is a terpene cyclase/mutase family member, phylogenetic tree Brassica rapa subsp. pekinensis
additional information comparison of active-site residues Brassica rapa subsp. pekinensis