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Literature summary for 5.4.99.7 extracted from

  • Tian, B.X.; Eriksson, L.A.
    Catalytic mechanism and product specificity of oxidosqualene-lanosterol cyclase: a QM/MM study (2012), J. Phys. Chem. B, 116, 13857-13862.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
H232S site-directed mutagenesis, mutant energy profile compared to the wild-type enzyme Homo sapiens
H232T site-directed mutagenesis, mutant energy profile compared to the wild-type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(3S)-2,3-epoxy-2,3-dihydrosqualene Homo sapiens
-
lanosterol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol catalytic mechanism involving His232 via intermediates parkeol and protosta-12,24-dien-3-beta-ol, quantum mechanics/molecular mechanics, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-2,3-epoxy-2,3-dihydrosqualene
-
Homo sapiens lanosterol
-
?
(3S)-2,3-epoxy-2,3-dihydrosqualene reaction of wild-type enzyme, via intermediates parkeol and protosta-12,24-dien-3-beta-ol Homo sapiens lanosterol
-
?
(3S)-2,3-epoxy-2,3-dihydrosqualene reaction of mutant H232S Homo sapiens parkeol
-
?
(3S)-2,3-epoxy-2,3-dihydrosqualene reaction of mutant H232T Homo sapiens protosta-12,24-dien-3-beta-ol
-
?

Synonyms

Synonyms Comment Organism
OSC
-
Homo sapiens
Oxidosqualene-lanosterol cyclase
-
Homo sapiens

General Information

General Information Comment Organism
metabolism oxidosqualene-lanosterol cyclase is a key enzyme in the biosynthesis of cholesterol Homo sapiens
additional information H232 mutant energy profiles compared to the wild-type enzyme, overview Homo sapiens