Application | Comment | Organism |
---|---|---|
medicine | S23515 can exert hypolipidemic effects in addition to its hypotensive activities | Homo sapiens |
medicine | S23515 can exert hypolipidemic effects in addition to its hypotensive activities | Rattus norvegicus |
medicine | S23515 can exert hypolipidemic effects in addition to its hypotensive activities | Macaca fascicularis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BIBB 515 | - |
Homo sapiens | |
BIBB 515 | - |
Macaca fascicularis | |
BIBB 515 | - |
Rattus norvegicus | |
S23515 | - |
Homo sapiens | |
S23515 | - |
Macaca fascicularis | |
S23515 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-monoepoxysqualene | Homo sapiens | - |
lanosterol | - |
? | |
2,3-monoepoxysqualene | Rattus norvegicus | - |
lanosterol | - |
? | |
2,3-monoepoxysqualene | Macaca fascicularis | - |
lanosterol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Macaca fascicularis | - |
Cynomolgus | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
hepatocyte | primary hepatocyte | Homo sapiens | - |
hepatocyte | primary hepatocyte | Rattus norvegicus | - |
hepatocyte | primary hepatocyte | Macaca fascicularis | - |
THP-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-monoepoxysqualene | - |
Homo sapiens | lanosterol | - |
? | |
2,3-monoepoxysqualene | - |
Rattus norvegicus | lanosterol | - |
? | |
2,3-monoepoxysqualene | - |
Macaca fascicularis | lanosterol | - |
? | |
2,3:22,23-diepoxysqualene | - |
Homo sapiens | 24(S),25-epoxylanosterol | - |
? | |
2,3:22,23-diepoxysqualene | - |
Rattus norvegicus | 24(S),25-epoxylanosterol | - |
? | |
2,3:22,23-diepoxysqualene | - |
Macaca fascicularis | 24(S),25-epoxylanosterol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
OSC | - |
Homo sapiens |
OSC | - |
Rattus norvegicus |
OSC | - |
Macaca fascicularis |
oxidosqualene:lanosterol cyclase | - |
Homo sapiens |
oxidosqualene:lanosterol cyclase | - |
Rattus norvegicus |
oxidosqualene:lanosterol cyclase | - |
Macaca fascicularis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
S23515 | - |
Rattus norvegicus |