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Literature summary for 5.4.99.7 extracted from

  • Dehmlow, H.; Aebi, J.D.; Jolidon, S.; Ji, Y.H.; von der Mark, E.M.; Himber, J.; Morand, O.H.
    Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors (2003), J. Med. Chem., 46, 3354-3370.
    View publication on PubMed
Search for more literature for 5.4.99.7

Inhibitors

Inhibitors Comment Organism Structure
(4-bromophenyl)[4-[6-(cyclopropylmethylmethylamino)hexyloxy]phenyl]methanone IC50: 31.8 nM Homo sapiens
(4-bromophenyl)[4-[6-[(3-hydroxypropyl)methylamino]-hexyloxy]phenyl]methanone IC50: 15.7 nM Homo sapiens
allyl-6-[4-(4-bromophenyl)-1H-benzo[d][1,2]oxazin-7-yloxy]hexylmethylamine IC50: 4.1 nM Homo sapiens
allyl[6-[1-(4-bromophenyl)-3,4-dihydroisoquinolin-6-yloxy]hexyl]methylamine IC50: 7.9 nM Homo sapiens
allyl[6-[1-(4-bromophenyl)isoquinolin-6-yloxy]hexyl]methylamine IC50: 3.5 nM Homo sapiens
allyl[6-[3-(4-bromophenyl)-1-methyl-1H-indazol-6-yloxy]hexyl]methylamine IC50: 19.6 nM Homo sapiens
allyl[6-[3-(4-bromophenyl)benzo[b]thiophen-6-yloxy]hexyl]methylamine IC50: 5.6 nM Homo sapiens
allyl[6-[3-(4-bromophenyl)benzo[d]isothiazol-6-yloxy]hexyl]methylamine IC50: 2.9 nM Homo sapiens
allyl[6-[4-(4-bromophenyl)-2H-chromen-7-yloxy]hexyl]methylamine IC50: 11.4 nM Homo sapiens
allyl[6-[4-(4-bromophenyl)quinazolin-7-yloxy]hexyl]methylamine IC50: 12.3 nM Homo sapiens
allyl[6-[4-(6-bromo-1,1-dioxobenzo[d]isothiazol-3-yl)phenoxy]hexyl]methylamine IC50: 7.8 nM Homo sapiens
[4-[6-(allylmethylamino)hexyloxy]-2-hydroxyphenyl](4-bromophenyl)methanone IC50: 6.3 nM Homo sapiens
[4-[6-(allylmethylamino)hexyloxy]-2-methoxyphenyl](4-bromophenyl)methanone IC50: 4.6 nM Homo sapiens
[4-[6-(allylmethylamino)hexyloxy]-2-methylaminophenyl](4-bromophenyl)methanone IC50: 4.1 nM Homo sapiens
[4-[6-(allylmethylamino)hexyloxy]-2-methylsulfanylphenyl](4-bromophenyl)methanone IC50: 6.2 nM Homo sapiens
[4-[6-(allylmethylamino)hexyloxy]phenyl](4-bromophenol)methanone IC50: 5.4 nM Homo sapiens
[4-[6-(allylmethylamino)hexyloxy]phenyl](4-nitrophenyl)methanone IC50: 1.9 nM Homo sapiens
[4-[6-(allylmethylamino)hexyloxy]phenyl]-(4-fluorophenyl)methanone IC50: 6.7 nM Homo sapiens
[4-[6-(allylmethylamino)hexyloxy]phenyl]phenylmethanone IC50: 22.5 nM Homo sapiens
[6-[6-(allylmethylamino)hexyloxy]pyridin-3-yl](4-bromophenyl)methanone IC50: 8.7 nM Homo sapiens
[6-[6-(cyclopropylmethylamino)hexyloxy]phenyl](4-bromophenyl)methanone IC50: 35.3 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
2,3-Oxidosqualene cyclase
-
 Homo sapiens
hOSC
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000019
-
 IC50: 1.9 nM Homo sapiens [4-[6-(allylmethylamino)hexyloxy]phenyl](4-nitrophenyl)methanone
0.0000029
-
 IC50: 2.9 nM Homo sapiens allyl[6-[3-(4-bromophenyl)benzo[d]isothiazol-6-yloxy]hexyl]methylamine
0.0000035
-
 IC50: 3.5 nM Homo sapiens allyl[6-[1-(4-bromophenyl)isoquinolin-6-yloxy]hexyl]methylamine
0.0000041
-
 IC50: 4.1 nM Homo sapiens [4-[6-(allylmethylamino)hexyloxy]-2-methylaminophenyl](4-bromophenyl)methanone
0.0000041
-
 IC50: 4.1 nM Homo sapiens allyl-6-[4-(4-bromophenyl)-1H-benzo[d][1,2]oxazin-7-yloxy]hexylmethylamine
0.0000046
-
 IC50: 4.6 nM Homo sapiens [4-[6-(allylmethylamino)hexyloxy]-2-methoxyphenyl](4-bromophenyl)methanone
0.0000054
-
 IC50: 5.4 nM Homo sapiens [4-[6-(allylmethylamino)hexyloxy]phenyl](4-bromophenol)methanone
0.0000056
-
 IC50: 5.6 nM Homo sapiens allyl[6-[3-(4-bromophenyl)benzo[b]thiophen-6-yloxy]hexyl]methylamine
0.0000062
-
 IC50: 6.2 nM Homo sapiens [4-[6-(allylmethylamino)hexyloxy]-2-methylsulfanylphenyl](4-bromophenyl)methanone
0.0000063
-
 IC50: 6.3 nM Homo sapiens [4-[6-(allylmethylamino)hexyloxy]-2-hydroxyphenyl](4-bromophenyl)methanone
0.0000067
-
 IC50: 6.7 nM Homo sapiens [4-[6-(allylmethylamino)hexyloxy]phenyl]-(4-fluorophenyl)methanone
0.0000078
-
 IC50: 7.8 nM Homo sapiens allyl[6-[4-(6-bromo-1,1-dioxobenzo[d]isothiazol-3-yl)phenoxy]hexyl]methylamine
0.0000079
-
 IC50: 7.9 nM Homo sapiens allyl[6-[1-(4-bromophenyl)-3,4-dihydroisoquinolin-6-yloxy]hexyl]methylamine
0.0000087
-
 IC50: 8.7 nM Homo sapiens [6-[6-(allylmethylamino)hexyloxy]pyridin-3-yl](4-bromophenyl)methanone
0.0000114
-
 IC50: 11.4 nM Homo sapiens allyl[6-[4-(4-bromophenyl)-2H-chromen-7-yloxy]hexyl]methylamine
0.0000123
-
 IC50: 12.3 nM Homo sapiens allyl[6-[4-(4-bromophenyl)quinazolin-7-yloxy]hexyl]methylamine
0.0000157
-
 IC50: 15.7 nM Homo sapiens (4-bromophenyl)[4-[6-[(3-hydroxypropyl)methylamino]-hexyloxy]phenyl]methanone
0.0000196
-
 IC50: 19.6 nM Homo sapiens allyl[6-[3-(4-bromophenyl)-1-methyl-1H-indazol-6-yloxy]hexyl]methylamine
0.0000225
-
 IC50: 22.5 nM Homo sapiens [4-[6-(allylmethylamino)hexyloxy]phenyl]phenylmethanone
0.0000318
-
 IC50: 31.8 nM Homo sapiens (4-bromophenyl)[4-[6-(cyclopropylmethylmethylamino)hexyloxy]phenyl]methanone
0.0000353
-
 IC50: 35.3 nM Homo sapiens [6-[6-(cyclopropylmethylamino)hexyloxy]phenyl](4-bromophenyl)methanone