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Literature summary for 5.4.99.7 extracted from

  • Ceruti, M.; Viola, F.; Balliano, G.; Milla, P.; Roma, G.; Grossi, G.; Rocco, F.
    Synthesis of (E)- and (Z)-29-methylidyne-2,3-oxidosqualene derivatives as inhibitors of liver and yeast oxidosqualene cyclase (2002), J. Chem. Soc. Perkin Trans., 1, 1477-1486.
No PubMed abstract available
Search for more literature for 5.4.99.7

Inhibitors

Inhibitors Comment Organism Structure
(18E)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene IC50: 0.03 mM Saccharomyces cerevisiae
(18E)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene IC50: 0.05 mM Sus scrofa
(18Z)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene IC50: 0.05 mM Saccharomyces cerevisiae
(18Z)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene IC50: 0.06 mM Sus scrofa
(22E)-24-methylidene-30-nor-2,3-oxidosqualene IC50: above 0.1 mM Saccharomyces cerevisiae
(22E)-24-methylidene-30-nor-2,3-oxidosqualene IC50: above 0.1 mM Sus scrofa
(22Z)-24-methylidene-30-nor-2,3-oxidosqualene IC50: above 0.1 mM Saccharomyces cerevisiae
(22Z)-24-methylidene-30-nor-2,3-oxidosqualene IC50: above 0.1 mM Sus scrofa
(5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene + (5Z,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene, IC50: 0.06 mM Sus scrofa
(5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene + (5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.05 mM Saccharomyces cerevisiae
(5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene + (5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.02 mM Sus scrofa
(5Z,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene + (5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene, IC50: 0.06 mM Sus scrofa
(5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene + (5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.05 mM Saccharomyces cerevisiae
(5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene + (5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.02 mM Sus scrofa
(6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene + (6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM Saccharomyces cerevisiae
(6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene + (6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM Sus scrofa
(6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene + (6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM Saccharomyces cerevisiae
(6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene + (6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM Sus scrofa
3-(3,7-Dimethyl-octadeca-3,7,11,15-tetraenyl)-2,2-dimethyl-oxirane IC50: 0.0015 mM Saccharomyces cerevisiae
3-(3,7-Dimethyl-octadeca-3,7,11,15-tetraenyl)-2,2-dimethyl-oxirane IC50: 0.0035 mM Sus scrofa

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Sus scrofa
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
 IC50: 0.0015 mM Saccharomyces cerevisiae 3-(3,7-Dimethyl-octadeca-3,7,11,15-tetraenyl)-2,2-dimethyl-oxirane
0.0035
-
 IC50: 0.0035 mM Sus scrofa 3-(3,7-Dimethyl-octadeca-3,7,11,15-tetraenyl)-2,2-dimethyl-oxirane
0.02
-
 + (5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.02 mM Sus scrofa (5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
0.02
-
 + (5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.02 mM Sus scrofa (5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
0.03
-
 IC50: 0.03 mM Saccharomyces cerevisiae (18E)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
0.03
-
 + (6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM Sus scrofa (6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
0.03
-
 + (6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM Saccharomyces cerevisiae (6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
0.03
-
 + (6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM Sus scrofa (6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
0.03
-
 + (6Z,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene, IC50: 0.03 mM Saccharomyces cerevisiae (6E,10E,14E,18E)-22,23-epoxy-6-ethynyl-2,10,15,19,23-pentamethyltetracosa-2,6,10,14,18-pentaene
0.05
-
 IC50: 0.05 mM Saccharomyces cerevisiae (18Z)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
0.05
-
 IC50: 0.05 mM Sus scrofa (18E)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
0.05
-
 + (5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.05 mM Saccharomyces cerevisiae (5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
0.05
-
 + (5Z,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene, IC50: 0.05 mM Saccharomyces cerevisiae (5E,9E,13E,17E)-21,22-epoxy-5-ethynyl-2,9,14,18,22-pentamethyltricosa-2,5,9,13,17-pentaene
0.06
-
 IC50: 0.06 mM Sus scrofa (18Z)-29-methylidene-20,21,22,23,24,30-hexanor-2,3-oxidosqualene
0.06
-
 + (5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene, IC50: 0.06 mM Sus scrofa (5Z,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene
0.06
-
 + (5Z,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene, IC50: 0.06 mM Sus scrofa (5E,9E,13E,17E)-21,22-epoxy-2,9,14,18,22-pentamethyl-5-(trimethylsilylethynyl)tricosa-2,5,9,13,17-pentaene
0.1
-
 IC50: above 0.1 mM Sus scrofa (22Z)-24-methylidene-30-nor-2,3-oxidosqualene
0.1
-
 IC50: above 0.1 mM Saccharomyces cerevisiae (22Z)-24-methylidene-30-nor-2,3-oxidosqualene
0.1
-
 IC50: above 0.1 mM Sus scrofa (22E)-24-methylidene-30-nor-2,3-oxidosqualene
0.1
-
 IC50: above 0.1 mM Saccharomyces cerevisiae (22E)-24-methylidene-30-nor-2,3-oxidosqualene