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Literature summary for 5.4.99.5 extracted from

  • Kim, M.; Lee, J.; Heo, L.; Han, S.W.
    Putative bifunctional chorismate mutase/prephenate dehydratase contributes to the virulence of Acidovorax citrulli (2020), Front. Plant Sci., 11, 569552.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Paracidovorax citrulli
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Paracidovorax citrulli KACC17005
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chorismate the bifunctional enzyme (cf. EC 4.2.1.51) possesses two distinct domains: chorismate mutase and prephenate dehydratase Paracidovorax citrulli Prephenate
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 r
Chorismate the bifunctional enzyme (cf. EC 4.2.1.51) possesses two distinct domains: chorismate mutase and prephenate dehydratase Paracidovorax citrulli KACC17005 Prephenate
-
 r

Synonyms

Synonyms Comment Organism
Chorismate mutase/prephenate dehydratase bifunctional enzyme, cf. EC 4.2.1.51 Paracidovorax citrulli
CmpAc bifunctional enzyme, cf. EC 4.2.1.51 Paracidovorax citrulli

General Information

General Information Comment Organism
drug target potential targets for developing virulence inhibitors against Acidovorax citrulli, a plant pathogenic bacterium that causes bacterial fruit blotch in cucurbit crops Paracidovorax citrulli
malfunction Acidovorax citrulli strain lacking the bifunctional chorismate mutase/prephenate dehydratase (CmpAc, cf. EC 4.2.1.51), are significantly less virulent on watermelon in the germinated seed inoculation and leaf infiltration assays. The strain shows reduced twitching halo production and enhanced biofilm formation. the strain is less tolerant to osmotic stress but more tolerant to antibiotics (polymyxin B) Paracidovorax citrulli
physiological function key enzyme in the shikimate pathway. It produces aromatic amino acids. Auxotrophic assays demonstrate that the bifunctional chorismate mutase/prephenate dehydratase (CmpAc, cf. EC 4.2.1.51) is required for the biosynthesis of phenylalanine, but not tyrosine. The comparative proteomic analysis revealed that CmpAc is mostly involved in cell wall/membrane/envelop biogenesis Paracidovorax citrulli