Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.4.99.5 extracted from

  • Cotton, R.G.H.; Gibson, F.
    The biosynthesis of phenylalanine and tyrosine enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase (1965), Biochim. Biophys. Acta, 100, 76-88.
    View publication on PubMed
Search for more literature for 5.4.99.5

Inhibitors

Inhibitors Comment Organism Structure
L-Phe
-
 Escherichia coli
L-Phe chorismate mutase P is strongly inhibited, chorismate mutase T is not inhibited Klebsiella aerogenes
L-Tyr
-
 Escherichia coli
L-Tyr slight inhibition of chorismate mutase P and no inhibition of chorismate mutase T Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Chorismate Escherichia coli in the biosynthesis of Phe and Tyr, there are two enzymes or enzyme complexes metabolizing chorismate, one leading through prephenate to phenylpyruvate and the other leading through prephenate to 4-hydroxyphenylpyruvate ?
-
 ?
Chorismate Klebsiella aerogenes in the biosynthesis of Phe and Tyr, there are two enzymes or enzyme complexes metabolizing chorismate, one leading through prephenate to phenylpyruvate and the other leading through prephenate to 4-hydroxyphenylpyruvate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Klebsiella aerogenes
-
 2 enzyme forms: chorismate mutase P and chorismate mutase T. Chorismate mutase P is associated with prephenate dehydratase, chorismate mutase T is associated with prephenate dehydrogenase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Chorismate
-
 Escherichia coli Prephenate
-
 ?
Chorismate
-
 Klebsiella aerogenes Prephenate
-
 ?
Chorismate in the biosynthesis of Phe and Tyr, there are two enzymes or enzyme complexes metabolizing chorismate, one leading through prephenate to phenylpyruvate and the other leading through prephenate to 4-hydroxyphenylpyruvate Escherichia coli ?
-
 ?
Chorismate in the biosynthesis of Phe and Tyr, there are two enzymes or enzyme complexes metabolizing chorismate, one leading through prephenate to phenylpyruvate and the other leading through prephenate to 4-hydroxyphenylpyruvate Klebsiella aerogenes ?
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
42
-
 4 min, 59% loss of chorismate mutase P activity, no effect on chorismate mutase T activity Klebsiella aerogenes