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Literature summary for 5.4.99.41 extracted from
- Enzymatic synthesis of an indole diterpene by an oxidosqualene cyclase: mechanistic, biosynthetic, and phylogenetic implications (2003), J. Am. Chem. Soc., 125, 9002-9003.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Saccharomyces cerevisiae lacking lanosterol synthase activity | Arabidopsis thaliana |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
isoform LUP1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-(omega-oxidogeranlygeranyl)indole | substrate undergoes protonation, epoxide ring opening, and chair-chair bicyclization to cation. A Markovnikov intermediate is strongly favored, and its cyclization to indole forms the final product | Arabidopsis thaliana | petromindole | - |
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