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Literature summary for 5.4.99.13 extracted from

  • Moore, B.S.; Eisenberg, R.; Weber, C.; Bridges, A.; Nanz, D.; Robinson, J.A.
    On the stereospecificity of the coenzyme B12-dependent isobutyryl-CoA mutase reaction (1995), J. Am. Chem. Soc., 117, 11285-11291.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-methylpropanoyl-CoA Streptomyces virginiae biosynthesis of the antibiotic monesin-A butanoyl-CoA
-
r
2-methylpropanoyl-CoA Streptomyces virginiae A3823.5 biosynthesis of the antibiotic monesin-A butanoyl-CoA
-
r

Organism

Organism UniProt Comment Textmining
Streptomyces virginiae
-
A3823.5
-
Streptomyces virginiae A3823.5
-
A3823.5
-

Purification (Commentary)

Purification (Comment) Organism
partial, using ammonium sulfate precipitation, and DEAE-Sepharose column chromatography Streptomyces virginiae

Reaction

Reaction Comment Organism Reaction ID
2-methylpropanoyl-CoA = butanoyl-CoA loss of stereocontrol during the reaction Streptomyces virginiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methylpropanoyl-CoA
-
Streptomyces virginiae butanoyl-CoA
-
r
2-methylpropanoyl-CoA biosynthesis of the antibiotic monesin-A Streptomyces virginiae butanoyl-CoA
-
r
2-methylpropanoyl-CoA
-
Streptomyces virginiae A3823.5 butanoyl-CoA
-
r
2-methylpropanoyl-CoA biosynthesis of the antibiotic monesin-A Streptomyces virginiae A3823.5 butanoyl-CoA
-
r
isobutyrylcarba(dethia)-CoA
-
Streptomyces virginiae butyrylcarba(dethia)-CoA
-
r
isobutyrylcarba(dethia)-CoA
-
Streptomyces virginiae A3823.5 butyrylcarba(dethia)-CoA
-
r

Synonyms

Synonyms Comment Organism
ICM
-
Streptomyces virginiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
the reaction is incubated at darkness Streptomyces virginiae
30
-
assay at, half life of the mutase is of 60 min at 30ºC Streptomyces virginiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Streptomyces virginiae