Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.4.4.7 extracted from

  • Yu, Z.; Schneider, C.; Boeglin, W.E.; Brash, A.R.
    Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3 (2005), Biochim. Biophys. Acta, 1686, 238-247.
    View publication on PubMed
Search for more literature for 5.4.4.7

Cloned(Commentary)

Cloned (Comment) Organism
mutant enzymes are expressed in Escherichia coli and COS7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R396S no detectable activity with (12R)-HPETE Homo sapiens
V500F no detectable activity with (12R)-HPETE Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ contains Fe2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(12R)-HPETE preferred substrate Homo sapiens (8R)-hydroxy-(11R,12R)- epoxyeicosa-(5Z,9E,14Z)-trienoic acid
-
 ?
(15S)-HPETE
-
 Homo sapiens (13R)-hydroxy-(14S,15S)-epoxyeicosa-(5Z,8Z,11Z)-trienoic acid
-
 ?

Synonyms

Synonyms Comment Organism
eLOX3
-
 Homo sapiens
epidermal lipoxygenase-3
-
 Homo sapiens
hepoxilin synthase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme participates in the normal process of skin differentiation Homo sapiens