Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ethanolamine | stimulates activity of mutant enzyme Lys265Arg | Escherichia coli | |
methylamine | stimulates activity of mutant enzyme Lys265Arg | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
mutant enzyme Lys265Arg, overexpression | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
L265E | mutant Lys265Arg has 2% of the enzymatic activity compared to the wild-type enzyme, the dimeric structure is not influenced, activity is stimulated by addition of exogenous amines such as ethanolamine and methylamine | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-4-Amino-5-oxopentanoate | Escherichia coli | 4,5-dioxovalerate and 4,5-diaminovalerate are reaction intermediates | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
wild-type and active site mutant K265R | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-4-Amino-5-oxopentanoate | - |
Escherichia coli | 5-Amino-4-oxopentanoate | - |
? | |
(S)-4-Amino-5-oxopentanoate | 4,5-dioxovalerate and 4,5-diaminovalerate are reaction intermediates | Escherichia coli | ? | - |
? | |
4,5-Diaminovalerate | is a substrate for the pyridoxal 5'-phosphate form of the enzyme | Escherichia coli | ? | - |
? | |
4,5-Dioxovalerate | is a substrate for the pyridoxamine form of the enzyme | Escherichia coli | 5-Amino-4-oxopentanoate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Escherichia coli |