Literature summary for 5.4.3.6 extracted from

Wu, B.; Szymanski, W.; Wijma, H.J.; Crismaru, C.G.; de Wildeman, S.; Poelarends, G.J.; Feringa, B.L.; Janssen, D.B.
Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase (2010), Chem. Commun. (Camb. ), 46, 8157-8159.

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Protein Variants

Protein Variants	Comment	Organism
C107F	inactive	Streptomyces globisporus
C107F	inactive	Chondromyces crocatus
C107F	inactive	Cupriavidus crocatus
H93F	the mutation abolishes all enzymatic activity	Streptomyces globisporus
H93F	the mutation abolishes all enzymatic activity	Chondromyces crocatus
H93F	the mutation abolishes all enzymatic activity	Cupriavidus crocatus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.028	-	L-tyrosine	pH and temperature not specified in the publication	Streptomyces globisporus
0.377	-	L-tyrosine	pH and temperature not specified in the publication	Chondromyces crocatus
0.377	-	L-tyrosine	pH and temperature not specified in the publication	Cupriavidus crocatus

Organism

Organism	UniProt	Comment	Textmining
Chondromyces crocatus	-	-	-
Cupriavidus crocatus	-	-	-
Streptomyces globisporus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine	-	Chondromyces crocatus	(R)-beta-tyrosine	preferred product	r
L-tyrosine	-	Cupriavidus crocatus	(R)-beta-tyrosine	preferred product	r
L-tyrosine	-	Streptomyces globisporus	(S)-beta-tyrosine	preferred product	r
additional information	L-phenylalanine is no substrate	Streptomyces globisporus	?	-	?
additional information	L-phenylalanine is no substrate	Chondromyces crocatus	?	-	?
additional information	L-phenylalanine is no substrate	Cupriavidus crocatus	?	-	?

Synonyms

Synonyms	Comment	Organism
TAM	-	Streptomyces globisporus
TAM	-	Chondromyces crocatus
TAM	-	Cupriavidus crocatus
tyrosine aminomutase	-	Streptomyces globisporus
tyrosine aminomutase	-	Chondromyces crocatus
tyrosine aminomutase	-	Cupriavidus crocatus

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
7000	-	L-tyrosine	pH and temperature not specified in the publication	Chondromyces crocatus
7000	-	L-tyrosine	pH and temperature not specified in the publication	Cupriavidus crocatus
10000	-	L-tyrosine	pH and temperature not specified in the publication	Streptomyces globisporus

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
1900	-	L-tyrosine	pH and temperature not specified in the publication	Chondromyces crocatus
1900	-	L-tyrosine	pH and temperature not specified in the publication	Cupriavidus crocatus
36000	-	L-tyrosine	pH and temperature not specified in the publication	Streptomyces globisporus

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Release 2023.1 (January 2023)