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Literature summary for 5.4.2.8 extracted from

  • Andreotti, G.; Monti, M.C.; Citro, V.; Cubellis, M.V.
    Heterodimerization of two pathological mutants enhances the activity of human phosphomannomutase2 (2015), PLoS ONE, 10, e0139882 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.2.8

Activating Compound

Activating Compound Comment Organism Structure
D-Glucose 1,6-bisphosphate
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
F119L the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
R141H inactive Homo sapiens
R141H/F119L the stability-impaired mutant has wild type activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15305
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-glucose 1-phosphate
-
 Homo sapiens D-glucose 6-phosphate
-
 ?
alpha-D-mannose 1-phosphate
-
 Homo sapiens D-mannose 6-phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 27950, electrospray ionization mass spectrometry Homo sapiens

Synonyms

Synonyms Comment Organism
phosphomannomutase 2
-
 Homo sapiens
PMM2
-
 Homo sapiens