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Literature summary for 5.4.2.8 extracted from
- Serum and glucocorticoid-regulated kinase Sgk1 inhibits insulin-dependent activation of phosphomannomutase 2 in transfected COS-7 cells (2005), Am. J. Physiol., 288, C148-155.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Insulin | incubation with insulin for 45min led to a more than twofold activation of the enzyme | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| serum- and glucocorticoid-regulated kinase | Sgk1 decreases the enzymatic activity of PMM2 in the basal state and upon insulin stimulation in intact COS-7 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | expression in COS-7 cells | Homo sapiens | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-mannose-1-phosphate | - |
Homo sapiens | mannose-6-phosphate | - |
r |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PMM2 | - |
Homo sapiens |
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